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This game also features a Free Spins bonus with multipliers up to 500x your bet.<br><br>Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and had participants from various geographical areas. This type of heterogeneity is essential for pragmatic trials to be valid and helps to reduce the chance of bias in the results. However, too much heterogeneity can cause issues with the design of the trial.<br><br>Pragmatic Play is one of the major players in the live casino market, provides an array of traditional table games such as Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta offer a real-life gambling experience for players, as well as a wide range of virtual betting options. The company has also developed several interactive game shows to make online gambling fun. 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They should, however, not be used to replace the need for explanation studies.<br><br>The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool was designed to define the features of a pragmatic study,  [https://bookmarkmoz.com/story18334386/the-hidden-secrets-of-pragmatic-genuine 프라그마틱 무료체험] including recruitment, design and delivery of the intervention, and the follow-up.<br><br>There is a positive trend in the number of pragmatic trials that have been published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to note that the majority of these trials were conducted in primary care settings.