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It also comes with an extremely lucrative Free Spins feature with multipliers that can reach up to 500x the amount bet.<br><br>A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for a pragmatic trial to be valid and to reduce bias in the results is also essential. However too much heterogeneity could result in problems with the design of the trial.<br><br>Pragmatic Play is also a major player on the live casino market, offering an extensive selection of classic table games such as Blackjack and Roulette in a variety of versions. Pragmatic Play's live studios in Romania and Malta provide a genuine gaming experience for its customers and offer an extensive selection of virtual betting options. The company has also developed various interactive games to make online gambling fun. 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They are simple to navigate and you can play them any time you have an internet connection. Some Pragmatic Play sites even allow you to test your luck while on the move using the practice mode. This will help you become familiar with the rules of the game and features prior to playing with real money.<br><br>Legality<br><br>Pragmatic Play has earned a name for itself by providing top-quality games and an outstanding user experience. Its software can be used on mobile devices and in a variety of languages. Despite its infancy it has established itself as a top casino gaming platform. The most recent releases include Wolves which is a five-reel video slot with a healthful RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.<br><br>Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are usually commissioned by policymakers and practitioners to help inform their decisions. They can also be used to determine the causal relationship between an intervention with its outcomes. They should not, however be used to replace the need for explanation studies.<br><br>The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool sought to define the elements of a pragmatic study, including the recruitment process, the design and delivery of the intervention, and the follow-up.<br><br>There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs), yielded 34 articles, as shown in red in Figure 2. This is an indication that the health sciences community is becoming more acquaint to the issue of pragmatics. It is important to remember, however, that the majority were conducted in primary care settings.