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Despite its infancy, it has already established itself as a premier casino gaming platform. Wolves is one of the most recent releases which is a five-reel slot machine with a hefty RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.<br><br>The goal of pragmatic trials is to replicate real-life situations and achieve maximum validity externally. They are usually ordered by policymakers and practitioners to help inform their decisions. They can also be used to determine the cause-effect relationship of an intervention and its results. However, they shouldn't be used to substitute for the use of explanation studies.<br><br>The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study that includes recruitment, design, delivery of the intervention and its follow-up.<br><br>There is an encouraging increase in the number pragmatic trials that have been published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.