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Wolves is one of its latest releases that is a 5-reel slot machine with a hefty RTP and impressive graphics. Its other notable titles are Wolf Gold and Chilli Heat.<br><br>Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically requested by practitioners and policymakers in order to inform their decisions. They can be used to determine the causal relationship between an intervention with its outcomes. However, they should not be used to substitute for  [http://bbs.xinhaolian.com/home.php?mod=space&uid=4689075 프라그마틱 슬롯] the use of explanation studies.<br><br>The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the practice and policy decision-making. They also suggested the framework for pragmatic trials, called PRECIS.2 This tool attempted to define the characteristics of a practical trial which includes the recruitment process, the design and delivery of the intervention, and follow-up.<br><br>The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of these trials were conducted in primary care settings.