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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically focused on the practical aspects of study design, including the recruitment and consent process in adherence, as well as the use of standard equipment.

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A pragmatic study that involves a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be valid and reduce bias in results, is also necessary. Too much heterogeneity, however can result in problems with the trial design.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. Usually, they are requested by practitioners and policymakers to help guide their decisions. They are also a good method to determine the causal relationship between the intervention and its effects. However, they should not be used to replace explanatory studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials that inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic research study, including recruitment, design, delivery of the intervention, and follow-up.

There is a positive increase in the number of pragmatic trials published. A recent Medline search using the keywords naturalistic and 프라그마틱 슬롯무료 프라그마틱 슬롯 무료 체험 - discover here - pragmatic, limited to randomized controlled trials (RCTs), yielded 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.