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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often characterized by a focus on the practical aspects of the study design, such as the recruitment and consent process as well as adherence to the use of routinely available equipment.

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Pragmatic is a software developer that provides a variety of casino games for online gambling platforms. Pragmatic's iGaming software is used by leading operators as well as casinos that are located in the land. The company offers front-end site design tools, analysis tools and marketing, promotions, security payment systems, customer support and bug-reporting. In addition, the company provides its users a safe environment with high-quality graphics as well as gaming.

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A pragmatic trial that uses a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be valid and also helps reduce the chance of bias in the results. A high degree of heterogeneity, however can result in problems with the design of the trial.

Pragmatic Play, one of the major players in the live casino market, provides various classic table games like Blackjack and Roulette. The company's live studios in Romania and Malta offer an authentic gambling experience for players and offer a wide range of virtual betting options. The company has also created various interactive games to make online gambling enjoyable. Some of these shows feature live hosts, while others are hosted by celebrities from the industry.

Mobile compatibility

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In addition to their mobile-friendly slots, Pragmatic Play also offers table games and live dealer casinos. The company is licensed by a variety of regulatory bodies, including Malta Gaming Authority and UK Gambling Commission. The games of the company are secured by top-of-the-line encryption and its security team is on hand to assist players in any situation.

Pragmatic Play's slot games are very popular with newbies and seasoned players. They have modern graphics and traditional themes. Many of them have progressive jackpots and come with multiple bonus rounds and paylines. They are also not very volatile which means you can be sure to enjoy a long gaming session with them.

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Legality

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. Usually, they are commissioned by policymakers and practitioners to guide their decisions. They can also be a great method to determine the cause-effect relationship between an intervention and its outcomes. However, they shouldn't be used as a substitute for explanation trials.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis as well as pragmatic trials that inform the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic research study that includes recruitment, design, implementation of the intervention, and follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of studies were conducted in primary-care settings.