10 Pragmatic Free Trial Tricks All Experts Recommend

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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized by their focus on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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RTP

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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for pragmatic trials to be valid and reduce bias in results, is also necessary. However too much heterogeneity could result in issues with the design of the trial.

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Mobile compatibility

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Legality

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The purpose of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. They are usually requested by policy makers and practitioners to inform their decision making. They are also a good way to identify the causal relationship between an intervention and its results. However, they shouldn't be used in lieu for explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they should serve as an alternative to them. Schwartz and Lellouch1 made the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial which includes the recruitment process, the design and delivery of the intervention, and the follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.