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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often characterized by a focus on the practical aspects of the study design, such as the recruitment and consent process in adherence, as well as the use of commonly available equipment.

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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for practical trials to be valid and helps reduce the chance of bias in the results. A high degree of heterogeneity, however, can cause problems with the trial design.

Pragmatic Play Pragmatic Play, one of the major players in the live casino market, provides various classic table games such as Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta offer an authentic gambling experience for players, as well as an extensive selection of virtual betting options. The company also offers a variety of game shows that make online gambling exciting and interactive. Some of these shows have live hosts, whereas others are hosted by famous personalities from the industry.

Mobile compatibility

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Legality

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The aim of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are typically commissioned by policymakers and practitioners in order to inform their decisions. They can also be used to assess the cause-effect relationship of an intervention with its outcomes. However, they should not be used to substitute for the use of explanation studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a practical study that includes recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the subject of pragmatism. It is important to keep in mind that the majority of these trials were conducted in primary care settings.