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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are usually characterized by a focus on the practical aspects of study design, such as recruitment and consent, adherence, and the use of standard equipment.

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A pragmatic trial that uses various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for a pragmatic trial to be reliable and reduce bias in results, is also necessary. However too much heterogeneity could lead to issues with the design of the trial.

Pragmatic Play is one of the biggest players on the live casino market, provides various classic table games such as Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta offer a real-life gaming experience for its customers, as well as an extensive selection of virtual betting options. The company also offers a variety of game shows which make online gambling fun and interactive. Some of these shows have live hosts, whereas others are hosted by celebrities from the industry.

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Pragmatic Play, a new player in the field of online casinos, has gained recognition for its mobile-friendly slot machines. Their games are optimized for mobile devices, and are powered by HTML5 technology. They are also certified by reputable gaming authorities to ensure fairness and transparency. This is a good sign for players as it means the games have been tested and validated to ensure randomness and fairness of every game.

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Pragmatic Play's slot games are very popular among both newcomers as well as experienced players. They have modern designs and traditional themes. A lot of them offer progressive jackpots as well as numerous paylines and bonus rounds. They aren't volatile, so you can enjoy a long gaming experience.

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Pragmatic Play is renowned for its top-notch games, and for providing a superior user experience. Its software is designed to work on mobile devices and is compatible with different languages. It has earned itself the status of one of the most popular gaming platforms for casinos despite its relative infancy. Its latest releases include Wolves which is a five-reel video slot with a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are usually commissioned by policy makers and practitioners to inform their decision making. They are also a good way to identify the cause-effect relationship between the intervention and its effects. They should, however, not be used to replace explanatory studies.

The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which prove the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study that includes the recruitment, design, and delivery of the intervention and follow-up.

There is a growing trend in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) resulted in 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. However, it is important to note that the majority of these trials were conducted in primary care settings.