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Pragmatic trials are those that are designed to provide information for real-world clinical practice. They are typically focused on the practical aspects of the research design, like the recruitment process and consent, adherence, and the use of routinely available equipment.

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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for practical trials to be valid and also reduces bias in the results. However too much heterogeneity could cause issues with the design of the trial.

Pragmatic Play, one of the major players in the live casino market, provides an array of traditional table games like Blackjack and Roulette. The live studios of the company in Romania and Malta offer customers an authentic gaming experience and a wide selection of virtual betting options. The company also hosts a variety of game shows that make online gambling more fun and interactive. Some of these shows are broadcast live, while others are hosted by famous personalities from the field.

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Pragmatic Play offers not only mobile-friendly slot machines, but also table games and live casino. The company is licensed and regulated by a variety of regulatory bodies which include the Malta Gaming Authority and UK Gambling Commission. The games are supported by top-of-the-line encryption technology and the security team is ready to assist players solve any issues they might face.

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Legality

Pragmatic Play has earned a reputation for providing high-quality games and a superior user experience. Its software is designed to work on mobile devices and supports multiple languages. It has established itself as one of the top casino gaming platforms despite its relatively young age. Wolves is one of its latest releases that is a 5-reel slot machine with a healthy RTP and stunning graphics. Its other notable titles are Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are usually ordered by policymakers and practitioners to inform their decisions. They can be used to determine the causality of an intervention and its results. However, they should not, be used to replace explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials can replace tests for explanations or if they should serve as a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove a physiological or clinical hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also proposed the framework for pragmatic trials, 프라그마틱 슬롯 추천 dubbed PRECIS.2 This tool sought to define the characteristics of a pragmatic trial which includes recruitment, design and delivery of the intervention, and the follow-up.

There is a positive increase in the number pragmatic trials published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the subject of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.