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Peritoneal Mesothelioma Asbestos Symptoms<br><br>Peritoneal mesothelioma asbestos symptoms typically affect the digestive system. This is due to asbestos fibers being taken in and are then embedded within the lining of your stomach, known as the peritoneum.<br><br>Over time, these fibres cause mutations to healthy peritoneal cell. In the end cancerous tumors develop in the peritoneum.<br><br>Mesothelioma is a difficult condition to identify. The early signs may be confused with other signs like hernias or irritable Bowel Syndrome.<br><br>Symptoms<br><br>When asbestos fibers are breathed in, they can be absorbed into the lungs and then travel throughout the body. From there, they can be stuck in the lining of the abdomen or other organs, causing inflammation and irritation that eventually leads to the growth of tumors. The process can take years to develop, and many victims are unaware of their asbestos exposure until it's too late.<br><br>Malignant peritoneal melanoma develops when asbestos fibers become trapped in the tissue that lines the abdominal cavity as well as other organs. It is the second most common mesothelioma type, however it can be difficult to diagnose because early symptoms are nonspecific and similar to those of digestive conditions. Patients suffering from peritoneal cancer typically have stomach pain, fatigue and gastrointestinal issues.<br><br>After a physical examination and reviewing medical history and a series tests in the laboratory, mesothelioma patients are diagnosed with peritoneal cancer. A CT scan and an X-ray may help doctors identify lumps or any other signs of illness. In some cases mesothelioma specialists may also request a biopsy for a more accurate diagnosis.<br><br>Peritoneal Mesothelioma Symptoms usually begin in the abdomen and may cause severe abdominal discomfort, bloating, and weight loss. They may also cause nausea and vomiting, as well as other digestive issues. Other symptoms include chest pain, swelling, and fatigue. It is crucial for patients to seek medical attention in the event of these symptoms as they may be caused by something other than mesothelioma.<br><br>Despite the difficulties of diagnosing peritoneal mesothelioma, victims typically receive the appropriate treatment to extend their lives. In most cases, treatment involves surgery and heated chemo.<br><br>If you or someone you love have been diagnosed with peritoneal mesothelioma, call our mesothelioma lawyers to learn more about what we can do to help. We can assist you in finding an expert in your area who can help you file an asbestos lawsuit against asbestos-related companies responsible for your exposure. We can also help you get the financial compensation you are entitled to. Complete our online form to begin the process. We can help you get the best possible outcome by working with the best mesothelioma lawyers ([https://historydb.date/wiki/Mcdermottoutzen4747 Related Web Page]).<br><br>Diagnosis<br><br>To determine if you have peritoneal msothelioma it is important to have an exhaustive medical history. Doctors will ask about the person's exposure to asbestos and when it happened. A physical exam will be conducted. Blood tests, X-rays and CT scans are typically used in the initial work-up.<br><br>Peritoneal mesothelioma is a difficult cancer to identify due to its lengthy period of latency. Patients might experience symptoms such as nausea, abdominal pain and fever that are similar to other conditions. These symptoms aren't specific and can confuse doctors. Mesothelioma, a rare cancer that can take years to show symptoms after asbestos exposure, is a rare illness.<br><br>Asbestos fibers inhaled or consumed are transported to the stomach lining, known as the peritoneum. Asbestos fibers that are sharp can irritate mesothelium once they reach the peritoneum. In time, this irritation causes inflammation and scar tissue formation. In the end, this causes abnormal cell growth and tumors develop.<br><br>Researchers are working on methods to detect mesothelioma at its earliest stages. Staging mesothelioma is important as it determines treatment options.<br><br>A mesothelioma specialist may perform paracentesis (percutaneous needle biopsy) to collect samples for tests in the laboratory. These tests can identify the type of cancer cells (epithelioid or sarcomatoid) within the tumor and help doctors determine the best treatment plan.<br><br>Mesothelioma specialists also evaluate a patient's stage of mesothelioma. The stage determines the most effective treatments and helps mesothelioma lawyers know which asbestos-related companies are responsible in [https://www.longisland.com/profile/peanutperu0 mesothelioma attorney] lawsuits.<br><br>A mesothelioma specialist examines the results of a biopsy they produce a pathology report that includes details about the type of mesothelioma. The report may also contain an assessment scale that reveals how far the cancer has spread within the body. The higher the stage, the less likely it is to respond to treatment. A lawyer can explain the implications of this to a particular client's case.<br><br>Treatment<br><br>When swallowed or inhaled, asbestos fibers become embedded in the tissues that line the abdomen and other organs. The fibers cause irritation to cells and cause DNA damage. In time, this can lead to the formation of tumors within the lining. Typically, peritoneal cancer is found in the lining that surrounds the abdomen. Peritoneal mesothelioma is rarer than pleural mesothelioma and usually affects women more.<br><br>The symptoms of peritoneal cancer are similar to those associated with gastrointestinal disorders such as Crohn's disease and irritable bowel syndrome and makes it difficult for doctors to identify. Because of this, early symptoms can be mistaken for normal ailments, and can last for months or years before a patient receives an mesothelioma-related diagnosis.<br><br>In addition to an extensive medical history, a physician will run imaging and blood tests to rule out other diseases and conditions that could trigger the same symptoms as mesothelioma. These tests will help to determine the best treatment options.<br><br>A biopsy is conducted by a physician to confirm the diagnosis. This is due to the fact that peritoneal msothelioma can in the abdominal liner. A biopsy is the process of removing small amounts of the affected area to be examined by pathologists. Biopsies can reveal cancerous cells as well as identify the type of mesothelioma.<br><br>If a peritoneal msothelioma has been confirmed doctors will discuss treatment options with patients. Generally, the goal of a treatment plan is to reduce the size and quantity of tumors. Surgery is usually the first line of defense, however, patients must also consider the possibility of chemotherapy and immunotherapy.<br><br>In contrast to the chest-based treatment for pleural Mesothelioma which is administered through the lungs, the treatment for peritoneal Mesothelioma is administered via intravenously or orally. Chemotherapy injections like heated intraperitoneal therapy (HIPEC), helped extend the survival of many patients. HIPEC is a method that was invented by mesothelioma pioneer Paul Sugarbaker.<br><br>Individuals with peritoneal asbestosis may be eligible to bring a lawsuit against negligent asbestos companies. A [https://perfectworld.wiki/wiki/7_Simple_Tips_To_Totally_Making_A_Statement_With_Your_Mesothelioma_Attorney mesothelioma lawyer] can evaluate the case of a patient and recommend legal options. Contact us today to get started. It is free, confidential and there is no commitment. We provide nationwide representation.<br><br>Prognosis<br><br>Mesothelioma cancer is extremely rare. Because doctors have limited experience with the disease, many patients are misdiagnosed as having other illnesses. A mesothelioma expert can assist patients with the diagnosis and ensure they receive right treatment.<br><br>The only known cause of peritoneal mesothelioma is asbestos exposure. Asbestos fibers can cause irritation to abdominal tissues as well as cell changes when inhaled or consumed. In time, this may result in tumors that develop into mesothelioma in the peritoneum.<br><br>Construction or manufacturing work is often the first place where asbestos exposure starts. These industries may employ asbestos-containing products including fireproofing, insulation. Asbestos can also be present in household items like flooring and roof tiles. Even the smallest amounts of exposure put a person at risk for mesothelioma. Due to the long time of latency the victims could be diagnosed with peritoneal msothelioma many decades after their initial exposure.<br><br>Peritoneal [https://blogfreely.net/foxweeder87/the-ultimate-cheat-sheet-for-mesothelioma-attorney-law-firm-of-danziger-and mesothelioma lawyer] symptoms could be similar to those of other conditions and be mistaken for a hernia, gastrointestinal issues like colitis or Crohn's disease, or other types of abdominal cancer. A lot of patients do not declare their asbestos exposure and do not seek medical attention. Specialists may recommend a biopsy to confirm the diagnosis of mesothelioma. A biopsy is the removal of tiny pieces of tissue to be tested. This procedure will reveal the stage of mesothelioma as well as whether it is epithelioid biphasic, or sarcomatoid.<br><br>If mesothelioma has not spread it is possible to remove the tumors. They will also offer an effective treatment. The doctor will also be able to determine whether the cancer has spread inside the abdomen. They may then recommend palliative care for the patient. For example, paracentesis to drain the abdomen of fluid.<br><br>The outlook for patients is worse when a mesothelioma has advanced. This is because the cancer can become resistant to certain treatments and may recur. The doctor might recommend the combination of chemotherapy and surgery. Surgical options include cytoreduction surgery with hyperthermic intraperitoneal chemotherapy. This combination is more likely than chemotherapy alone to improve the prognosis for the patient.
Peritoneal Mesothelioma Asbestos Symptoms<br><br>Peritoneal mesothelioma asbestos symptoms typically affect the digestive system. This is due to asbestos fibers being consumed and then absorbed in the lining of the stomach, known as the peritoneum.<br><br>Over time, these fibres cause mutations to healthy peritoneal cells. Cancerous tumors develop in the peritoneum as a result.<br><br>Mesothelioma is a difficult disease to recognize. Early signs may be confused with symptoms of other conditions such as hernias or irritable Bowel Syndrome.<br><br>Signs and symptoms<br><br>When asbestos fibers are inhaled they can enter the lungs and travel throughout the body. From there, they can be stuck in the abdominal lining or other organs, causing inflammation and irritation that eventually leads to tumor growth. This process can take years to develop and many victims are unaware of their asbestos exposure until it's too late.<br><br>Malignant peritoneal mesothelioma occurs when asbestos fibers are trapped in the tissue that lines the abdominal cavity as well as other organs. It is the second-most common [https://peatix.com/user/23946083 mesothelioma lawyer]. However it is often difficult for doctors to diagnose because the early symptoms are not specific. They can also be similar to gastrointestinal conditions. Patients suffering from peritoneal cancer typically suffer from stomach pain, fatigue and gastrointestinal issues.<br><br>After a physical examination followed by an examination of medical history and a series of laboratory tests, mesothelioma patients are diagnosed with peritoneal cancer. A CT scan and X-ray can aid in identifying lumps, or other indications of disease. In some cases mesothelioma physicians may require a biopsy to get a more precise diagnosis.<br><br>Peritoneal Mesothelioma symptoms usually start in the abdomen. They can cause severe abdominal discomfort, bloating, and weight loss. They can also trigger nausea and vomiting as well as other digestive issues. Other symptoms include chest pain, fatigue and swelling. If these symptoms are present it is essential to seek medical attention as they could be triggered by other illnesses.<br><br>Despite the difficulty in diagnosing peritoneal mesothelioma, patients typically receive the appropriate treatment to extend their lives. In most cases, this involves surgical treatment and heated chemotherapy.<br><br>If you or someone you love have been diagnosed with peritoneal cancer, contact our mesothelioma lawyers to learn what we can do to help. We can help you locate a mesothelioma expert near you who can assist you in filing a lawsuit against asbestos companies that are responsible for your exposure. We can also help ensure that you get the financial compensation you're entitled to. Fill out our online form to start the process. We can assist you to get the best possible outcome working with the best mesothelioma lawyers.<br><br>Diagnosis<br><br>To determine if you have peritoneal msothelioma it is important to have an extensive medical history. Doctors will ask about the person's exposure asbestos and when it happened. They may also conduct a physical exam. Blood tests, X-rays, and CT scans are commonly used in the initial work-up.<br><br>Due to the lengthy latency period, peritoneal mesothelioma can be difficult to diagnose. Patients may be afflicted by symptoms like abdominal pain, nausea and fever that are similar to other illnesses. These non-specific symptoms can confuse doctors. Mesothelioma is a rare type of cancer, and it can take years for symptoms to manifest after exposure to asbestos.<br><br>Asbestos fibers that are inhaled or consumed are transported to the stomach lining, known as the peritoneum. Once inside the peritoneum the asbestos fibers are sharp and irritate the mesothelium. In time this irritation can cause inflammation and scar tissue. This leads to abnormal cell growth and tumors.<br><br>Researchers are working on ways to detect the disease early. The stage of mesothelioma determines the treatment options.<br><br>A mesothelioma specialist may perform paracentesis (percutaneous needle biopsy) to collect samples for tests in the laboratory. These tests will reveal if the cancerous cells are epithelioid (epithelioid) or sarcomatoid (sarcomatoid) or biphasic within the tumor. This information aids doctors create a treatment plan.<br><br>Mesothelioma specialists can also determine a patient's stage of mesothelioma. The stage determines the most effective treatments and helps mesothelioma lawyers know which asbestos companies are liable in mesothelioma lawsuits.<br><br>When a mesothelioma specialist analyzes the results of a biopsy they prepare an a pathology report which contains details about the type of mesothelioma. The report could also include the staging scale, which indicates how far the cancer has spread within the body. The more advanced the stage of cancer the less likely a patient will respond to treatment. A lawyer can explain the significance of this in a client's situation.<br><br>Treatment<br><br>Asbestos fibers can be inhaled or ingested and become embedded in the tissue lining the abdomen and other organs. These fibers damage DNA and irritate cells. Over time, this leads to the formation of tumors within the lining. Typically, peritoneal mesothelioma develops in the lining of the abdomen called the peritoneum. Peritoneal Mesothelioma is more prevalent in women than pleural Mesothelioma but it is less common.<br><br>The symptoms of peritoneal cancer are similar to those associated with gastrointestinal disorders, such as Crohn's disease and irritable bowel syndrome which makes it difficult for doctors to identify. Initial symptoms may be misinterpreted as other conditions, and may persist for a long time, or even years before mesothelioma diagnosis is made.<br><br>A doctor will also conduct tests on blood and imaging to rule out other conditions or diseases that could trigger the same symptoms of mesothelioma. These tests will also aid in determining the most effective treatment options.<br><br>Because peritoneal mesothelioma develops in the abdominal lining The doctor will conduct biopsy to confirm a diagnosis. A biopsy is the process of removing small samples of the affected area for examination by pathologists. Biopsies can detect cancerous cells as well as identify the type of mesothelioma.<br><br>After a peritoneal msothelioma is confirmed doctors will discuss treatment options with patients. Generally speaking, the aim of a treatment plan is to decrease the size and quantity of tumors. Surgery is often the first option, but patients can also consider chemotherapy and immunotherapy.<br><br>Unlike the chest-based treatments for pleural mesothelioma, which are administered through the lung, the peritoneal mesothelioma treatment are administered intravenously or orally. Chemotherapies that are injected, such as heated intraperitoneal chemotherapy (HIPEC) have helped to extend survival for many patients. HIPEC is a procedure innovated by mesothelioma pioneer Paul Sugarbaker.<br><br>Individuals diagnosed with peritoneal mesothelioma could be able to bring an asbestos lawsuit against negligent companies. An experienced [https://www.diggerslist.com/66e8c37749fda/about mesothelioma lawyer] - [http://taikwu.com.tw/dsz/home.php?mod=space&uid=652506 taikwu.com.tw] - will review the case of a patient and suggest legal options. Contact us today to get started. Contact us today. It's completely free, confidential and there's no commitment. We provide nationwide representation.<br><br>Prognosis<br><br>Mesothelioma cancer is extremely rare. Because doctors have limited experience in diagnosing patients, many are mistakenly diagnosed with other illnesses. A mesothelioma expert can help patients to diagnose the disease and ensure they receive right treatment.<br><br>Asbestos exposure is only the one known cause of peritoneal mesothelioma. When asbestos fibers are breathed in or ingested, they could cause irritation to the abdominal tissues and cause cells to alter. In time, this may cause tumors to form mesothelioma of peritoneum.<br><br>The exposure to asbestos usually is a result of jobs in manufacturing or construction. These industries may use asbestos-containing materials including fireproofing, insulation. Asbestos is also present in household items such as roof tiles and flooring. Even very low levels of exposure can put a person at risk for mesothelioma. Because of the lengthy time of latency patients may be diagnosed with peritoneal mesothelioma several decades after their first exposure.<br><br>Peritoneal Mesothelioma can mimic other diseases. It is often mistaken for hernias or gastrointestinal problems like Crohn's or colitis and other types of abdominal cancers. Many patients do not declare their asbestos exposure and don't seek medical care. When mesothelioma is detected experts may suggest the procedure of a biopsy to make an accurate diagnosis. A biopsy involves the removal of a small portion of the affected tissue for testing. This test will reveal if the mesothelioma is epithelioid (epidermoid), the sarcomatoid (sarcomatoid) or biphasic.<br><br>If [https://peatix.com/user/23914344 mesothelioma attorneys] does not have spread and the doctors are able to remove the tumors. They will also provide an effective treatment. The doctor will also be able to determine if the cancer has been able to spread to the abdomen. They will then recommend palliative care for the patient. For instance paracentesis to remove abdominal fluid.<br><br>The outlook for patients is worse when a mesothelioma has advanced. This is because the tumors are able to become resistant to certain treatments, and they may recur. The doctor might recommend a combination of surgery and chemotherapy. Options for surgery include cytoreduction and hyperthermic intraperitoneal chemotherapy. This combination is more likely than chemotherapy on its own to improve the prognosis for patients.

Latest revision as of 10:10, 14 January 2025

Peritoneal Mesothelioma Asbestos Symptoms

Peritoneal mesothelioma asbestos symptoms typically affect the digestive system. This is due to asbestos fibers being consumed and then absorbed in the lining of the stomach, known as the peritoneum.

Over time, these fibres cause mutations to healthy peritoneal cells. Cancerous tumors develop in the peritoneum as a result.

Mesothelioma is a difficult disease to recognize. Early signs may be confused with symptoms of other conditions such as hernias or irritable Bowel Syndrome.

Signs and symptoms

When asbestos fibers are inhaled they can enter the lungs and travel throughout the body. From there, they can be stuck in the abdominal lining or other organs, causing inflammation and irritation that eventually leads to tumor growth. This process can take years to develop and many victims are unaware of their asbestos exposure until it's too late.

Malignant peritoneal mesothelioma occurs when asbestos fibers are trapped in the tissue that lines the abdominal cavity as well as other organs. It is the second-most common mesothelioma lawyer. However it is often difficult for doctors to diagnose because the early symptoms are not specific. They can also be similar to gastrointestinal conditions. Patients suffering from peritoneal cancer typically suffer from stomach pain, fatigue and gastrointestinal issues.

After a physical examination followed by an examination of medical history and a series of laboratory tests, mesothelioma patients are diagnosed with peritoneal cancer. A CT scan and X-ray can aid in identifying lumps, or other indications of disease. In some cases mesothelioma physicians may require a biopsy to get a more precise diagnosis.

Peritoneal Mesothelioma symptoms usually start in the abdomen. They can cause severe abdominal discomfort, bloating, and weight loss. They can also trigger nausea and vomiting as well as other digestive issues. Other symptoms include chest pain, fatigue and swelling. If these symptoms are present it is essential to seek medical attention as they could be triggered by other illnesses.

Despite the difficulty in diagnosing peritoneal mesothelioma, patients typically receive the appropriate treatment to extend their lives. In most cases, this involves surgical treatment and heated chemotherapy.

If you or someone you love have been diagnosed with peritoneal cancer, contact our mesothelioma lawyers to learn what we can do to help. We can help you locate a mesothelioma expert near you who can assist you in filing a lawsuit against asbestos companies that are responsible for your exposure. We can also help ensure that you get the financial compensation you're entitled to. Fill out our online form to start the process. We can assist you to get the best possible outcome working with the best mesothelioma lawyers.

Diagnosis

To determine if you have peritoneal msothelioma it is important to have an extensive medical history. Doctors will ask about the person's exposure asbestos and when it happened. They may also conduct a physical exam. Blood tests, X-rays, and CT scans are commonly used in the initial work-up.

Due to the lengthy latency period, peritoneal mesothelioma can be difficult to diagnose. Patients may be afflicted by symptoms like abdominal pain, nausea and fever that are similar to other illnesses. These non-specific symptoms can confuse doctors. Mesothelioma is a rare type of cancer, and it can take years for symptoms to manifest after exposure to asbestos.

Asbestos fibers that are inhaled or consumed are transported to the stomach lining, known as the peritoneum. Once inside the peritoneum the asbestos fibers are sharp and irritate the mesothelium. In time this irritation can cause inflammation and scar tissue. This leads to abnormal cell growth and tumors.

Researchers are working on ways to detect the disease early. The stage of mesothelioma determines the treatment options.

A mesothelioma specialist may perform paracentesis (percutaneous needle biopsy) to collect samples for tests in the laboratory. These tests will reveal if the cancerous cells are epithelioid (epithelioid) or sarcomatoid (sarcomatoid) or biphasic within the tumor. This information aids doctors create a treatment plan.

Mesothelioma specialists can also determine a patient's stage of mesothelioma. The stage determines the most effective treatments and helps mesothelioma lawyers know which asbestos companies are liable in mesothelioma lawsuits.

When a mesothelioma specialist analyzes the results of a biopsy they prepare an a pathology report which contains details about the type of mesothelioma. The report could also include the staging scale, which indicates how far the cancer has spread within the body. The more advanced the stage of cancer the less likely a patient will respond to treatment. A lawyer can explain the significance of this in a client's situation.

Treatment

Asbestos fibers can be inhaled or ingested and become embedded in the tissue lining the abdomen and other organs. These fibers damage DNA and irritate cells. Over time, this leads to the formation of tumors within the lining. Typically, peritoneal mesothelioma develops in the lining of the abdomen called the peritoneum. Peritoneal Mesothelioma is more prevalent in women than pleural Mesothelioma but it is less common.

The symptoms of peritoneal cancer are similar to those associated with gastrointestinal disorders, such as Crohn's disease and irritable bowel syndrome which makes it difficult for doctors to identify. Initial symptoms may be misinterpreted as other conditions, and may persist for a long time, or even years before mesothelioma diagnosis is made.

A doctor will also conduct tests on blood and imaging to rule out other conditions or diseases that could trigger the same symptoms of mesothelioma. These tests will also aid in determining the most effective treatment options.

Because peritoneal mesothelioma develops in the abdominal lining The doctor will conduct biopsy to confirm a diagnosis. A biopsy is the process of removing small samples of the affected area for examination by pathologists. Biopsies can detect cancerous cells as well as identify the type of mesothelioma.

After a peritoneal msothelioma is confirmed doctors will discuss treatment options with patients. Generally speaking, the aim of a treatment plan is to decrease the size and quantity of tumors. Surgery is often the first option, but patients can also consider chemotherapy and immunotherapy.

Unlike the chest-based treatments for pleural mesothelioma, which are administered through the lung, the peritoneal mesothelioma treatment are administered intravenously or orally. Chemotherapies that are injected, such as heated intraperitoneal chemotherapy (HIPEC) have helped to extend survival for many patients. HIPEC is a procedure innovated by mesothelioma pioneer Paul Sugarbaker.

Individuals diagnosed with peritoneal mesothelioma could be able to bring an asbestos lawsuit against negligent companies. An experienced mesothelioma lawyer - taikwu.com.tw - will review the case of a patient and suggest legal options. Contact us today to get started. Contact us today. It's completely free, confidential and there's no commitment. We provide nationwide representation.

Prognosis

Mesothelioma cancer is extremely rare. Because doctors have limited experience in diagnosing patients, many are mistakenly diagnosed with other illnesses. A mesothelioma expert can help patients to diagnose the disease and ensure they receive right treatment.

Asbestos exposure is only the one known cause of peritoneal mesothelioma. When asbestos fibers are breathed in or ingested, they could cause irritation to the abdominal tissues and cause cells to alter. In time, this may cause tumors to form mesothelioma of peritoneum.

The exposure to asbestos usually is a result of jobs in manufacturing or construction. These industries may use asbestos-containing materials including fireproofing, insulation. Asbestos is also present in household items such as roof tiles and flooring. Even very low levels of exposure can put a person at risk for mesothelioma. Because of the lengthy time of latency patients may be diagnosed with peritoneal mesothelioma several decades after their first exposure.

Peritoneal Mesothelioma can mimic other diseases. It is often mistaken for hernias or gastrointestinal problems like Crohn's or colitis and other types of abdominal cancers. Many patients do not declare their asbestos exposure and don't seek medical care. When mesothelioma is detected experts may suggest the procedure of a biopsy to make an accurate diagnosis. A biopsy involves the removal of a small portion of the affected tissue for testing. This test will reveal if the mesothelioma is epithelioid (epidermoid), the sarcomatoid (sarcomatoid) or biphasic.

If mesothelioma attorneys does not have spread and the doctors are able to remove the tumors. They will also provide an effective treatment. The doctor will also be able to determine if the cancer has been able to spread to the abdomen. They will then recommend palliative care for the patient. For instance paracentesis to remove abdominal fluid.

The outlook for patients is worse when a mesothelioma has advanced. This is because the tumors are able to become resistant to certain treatments, and they may recur. The doctor might recommend a combination of surgery and chemotherapy. Options for surgery include cytoreduction and hyperthermic intraperitoneal chemotherapy. This combination is more likely than chemotherapy on its own to improve the prognosis for patients.