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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are typically described by their focus on practical aspects of designing a study which include the recruitment process and consent, adhering and the use routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from different geographical regions. This type of heterogeneity is essential for pragmatic trials to be able to prove their validity and also helps reduce bias in the results. However, too much heterogeneity can lead to issues with the design of the trial.

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The purpose of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. Usually, they are commissioned by policymakers and 프라그마틱 슬롯체험 practitioners to help inform their decisions. They can be used to determine the causal relationship between an intervention and its results. However, they shouldn't be used as a substitute for the use of explanation studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they should be an alternative to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic study that include the recruitment process, the design and delivery of the intervention, and the follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatics. It is important to note that the majority of these studies were conducted in primary care settings.