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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are often characterized as a focus on the practical aspects of study design which include the recruitment process and consent, adhering and the use of routinely available equipment.
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A pragmatic trial that uses a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is vital for 프라그마틱 무료체험 pragmatic trials to be valid and lessen the chance of bias is also essential. Too much heterogeneity, however, can cause problems with the trial design.
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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually commissioned by policy makers and practitioners to inform their decision making. They can also be used to assess the causality of an intervention with its outcomes. However, 프라그마틱 무료 they shouldn't be used in lieu for explanatory studies.
The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the clinical or physiological hypothesis as well as pragmatic trials, which inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study that includes recruitment, design, delivery of the intervention, and follow-up.
There is a positive increase in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.