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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized as a focus on the practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of standard equipment.

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A pragmatic study that involves a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for practical trials to be valid and reduces the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.

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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually requested by practitioners and policy makers to inform their decision making. They can be used to determine the cause-effect relationship of an intervention and its results. However, they shouldn't be used in lieu for explanatory trials.

The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could be used to replace explanation tests or if they should be an addition to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also suggested an approach to pragmatic trials, called PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial which includes the recruitment process, the design and implementation of the intervention, and monitoring.

There is a growing increase in the number pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, 프라그마틱 슬롯무료 it is important to keep in mind that the majority of these trials were conducted in primary care settings.