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Pragmatic trials are trials designed to provide information for the practice of clinical trials in real life. They are often characterized by a focus on the practical aspects of study design, including recruitment and consent, adherence, and the use of standard equipment.
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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid and also helps to reduce the chance of bias in the results. A high degree of heterogeneity, however could cause issues with the design of the trial.
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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. Usually, they are commissioned by policymakers and practitioners to help inform their decisions. They also provide a useful method of determining the cause-effect relationship between an intervention and its outcomes. They should, however, not be used to replace the need for explanation studies.
The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or 프라그마틱 슬롯 무료체험 if they are a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study which includes recruitment, design, delivery of the intervention and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.