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Pragmatic trials are studies designed to inform the practice of clinical trials in real life. They are often characterized by a focus on the practical aspects of study design, such as the recruitment process and consent, adherence, and the use of commonly available equipment.

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A pragmatic trial that uses various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for practical trials to be valid, and it also helps reduce bias in the results. However excessive heterogeneity could result in problems with the design of the trial.

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The purpose of pragmatic trials is to mimic real-life scenarios and 프라그마틱 환수율 gain maximum credibility externally. They are usually requested by practitioners and policymakers to guide their decisions. They also provide a useful way to identify the causal relationship between an intervention and its outcomes. However, they shouldn't be used in lieu for explanatory studies.

The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial that include recruitment, design and delivery of the intervention, and monitoring.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, as shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note that the majority of studies were conducted in primary-care settings.