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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often characterized by a focus on the practical aspects of study design, such as the recruitment and consent process, adherence, and the use of standard equipment.

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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be able to prove their validity and helps to reduce the chance of bias in the results. Too much heterogeneity, 프라그마틱 슬롯 however can result in problems with the design of the trial.

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The aim of pragmatic trials is to mimic real-life scenarios and to achieve the highest level of validity externally. Usually, 프라그마틱 무료체험 they are ordered by policymakers and practitioners to help guide their decisions. They are also a good method of determining the cause-effect relationship between the intervention and its effects. However, they shouldn't be used in lieu for the use of explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study, including recruitment, design, implementation of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to keep in mind that the majority were conducted in primary-care settings.