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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are usually focused on practical aspects of the study design, including the recruitment process and consent as well as adherence to the use of commonly available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from various geographical areas. This type of heterogeneity that is crucial for a pragmatic trial to be valid and to reduce bias in the results is also essential. However too much heterogeneity could lead to issues with the design of the trial.

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Pragmatic Play is known for its top-quality games and also for providing an outstanding user experience. Its software is accessible on mobile devices and in a variety of languages. Despite its relative youth it has already established itself as a premier casino gaming platform. Wolves is one of its latest releases which is a five-reel slot machine that has a high RTP and 프라그마틱 무료슬롯 stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials aim to mimic real-life situations and attain maximum external validity. Usually, they are commissioned by policymakers and practitioners to help inform their decisions. They can also be a great way to identify the causal relationship between an intervention and its results. However, they shouldn't be used in lieu for the use of explanation studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study, including recruitment, design, delivery of the intervention, and follow-up.

There is an encouraging increase in the number of pragmatic trials published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of these studies were conducted in primary care settings.