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Pragmatic trials are studies designed to inform real-world clinical practice. They are usually focused on practical aspects of the research design, 프라그마틱 슬롯 추천 like recruitment and consent, adherence, and the use of commonly available equipment.

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A pragmatic study that involves a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for pragmatic trials to be valid and lessen the chance of bias, is also necessary. However, too much heterogeneity can cause issues with the design of the trial.

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The goal of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are usually requested by policy makers and practitioners to inform their decision making. They can also be used to assess the cause-effect relationship of an intervention with its outcomes. They should not, however be used to replace explanatory studies.

The concept of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide the practice and policy decisions. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, and follow-up.

There is a positive increase in the number pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is a sign that the health sciences community is becoming more sensitive to the subject of pragmatism. It is important to note, however, that the majority of studies were conducted in primary care settings.