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Pragmatic trials are those that are designed to inform the real-world practice of clinical. They are often focused on the practical aspects of research design, like the recruitment process and consent, adherence, and the use of commonly available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and participants from different geographic areas. This kind of heterogeneity is essential for pragmatic trials to be valid and also reduces the chance of bias in the results. However too much heterogeneity could cause issues with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. They are usually requested by policy makers and practitioners to inform their decision making. They also provide a useful method of determining the causal relationship between an intervention and its results. However, they shouldn't be used to substitute for the use of explanation studies.

The concept of pragmatism is controversial and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis as well as pragmatic trials that inform the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic research study that includes the recruitment, design, and delivery of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. However, it is important to note that the majority of these studies were conducted in primary care settings.