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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often characterized as a focus on the practical aspects of design which include recruitment and consent, adherence and the use of routinely available equipment.

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A pragmatic trial that uses various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be reliable and lessen the chance of bias, is also necessary. However too much heterogeneity could lead to problems with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. They are typically commissioned by policymakers and 프라그마틱 슬롯 체험 practitioners in order to guide their decisions. They can also be used to assess the cause-effect relationship of an intervention and its results. However, they should not be used to replace explanatory studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials can be used to replace explanation tests or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study which includes the recruitment, design, and delivery of the intervention and its follow-up.

There is an encouraging increase in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.