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Pragmatic trials are trials designed to provide information for the practice of clinical trials in real life. They are often characterized by their focus on practical aspects of study design, including recruitment and consent, adherence and the use routinely available equipment.
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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However, 프라그마틱 무료 슬롯 슬롯체험 (https://izumili.ru/bitrix/rk.php?goto=https://pragmatickr.Com) too much heterogeneity can lead to issues with the design of the trial.
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The purpose of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. They are usually commissioned by policymakers and practitioners in order to guide their decisions. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. They should, however, not be used to replace explanatory studies.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they are an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis, and pragmatic trials, which inform the policy and practice of. They also suggested a framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the elements of a pragmatic study that include the recruitment process, the design and implementation of the intervention, as well as follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. However, it is important to note that the majority of these trials were conducted in primary care settings.