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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described as a focus on the practical aspects of study design which include recruitment and consent, adherence and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and participants from different geographic areas. This type of heterogeneity is required for pragmatic trials to be able to prove their validity and also helps reduce the chance of bias in the results. However, too much heterogeneity can lead to issues with the design of the trial.

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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are usually ordered by policymakers and practitioners to inform their decisions. They also provide a useful method to determine the causality between an intervention and its results. They should not, however be used to replace explanatory studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis as well as pragmatic trials that inform policy and 프라그마틱 무료체험 슬롯버프 practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study, including recruitment, design, implementation of the intervention, and follow-up.

There is an encouraging increase in the number of pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more acquaint to the issue of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.