Ten Ways To Build Your Pragmatic Free Trial Empire
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Pragmatic trials are studies designed to inform real-world clinical practice. They are often described by their focus on practical aspects of designing a study that include recruitment and consent, adherence and the use of routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and had participants from various geographical areas. This kind of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. However, too much heterogeneity could cause issues with the trial design.
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Legality
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The aim of pragmatic trials is to simulate real-life scenarios and gain maximum credibility externally. They are usually commissioned by policymakers and practitioners to help inform their decisions. They also provide a useful method of determining the causal relationship between an intervention and its outcomes. However, they shouldn't be used in lieu for the use of explanation studies.
The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the decision-making process for policy and practice. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a practical trial which includes the recruitment process, the design and delivery of the intervention, as well as monitoring.
There is a positive increase in the number pragmatic trials that have been published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.