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Pragmatic trials are trials designed to provide information for real-world clinical practice. They are often described by their focus on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and included participants from different geographical regions. This kind of heterogeneity, that is crucial for a pragmatic trial to be valid and to reduce bias in the results is also essential. A high degree of heterogeneity, however could cause issues with the trial design.
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Pragmatic Play offers a large variety of games you can play for free before you decide whether to pay for them. These games are free and can be played on any device including laptops, desktops and smartphones. They can be played anywhere you're connected to the internet. They are easy-to-navigate. Some Pragmatic Play websites even let you test your luck while moving around by playing a test mode. This helps you familiarize yourself with the rules of the game and 프라그마틱 홈페이지 features prior to playing for real money.
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The goal of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. Usually, they are requested by practitioners and policymakers to inform their decisions. They can also be used to assess the cause-effect relationship of an intervention and its effects. However, they shouldn't be used in lieu for explanatory trials.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials can be used to replace explanation tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials, which inform the policy and practice of. They also suggested a framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a pragmatic study, including the recruitment process, the design and implementation of the intervention, as well as follow-up.
There is a positive increase in the number of pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatism. However, it is important to note that the majority of these trials were conducted in primary care settings.