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Pragmatic trials are those that are designed to inform real-world clinical practice. They are typically focused on practical aspects of the study design, including recruitment and consent in adherence, as well as the use of routinely available equipment.

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Pragmatic, a software company, offers a variety of casino games on online gambling platforms. Pragmatic's iGaming software is used by leading operators as well as land-based casinos. The company offers front-end website design tools, analysis and promotions, marketing, security, payment systems, customer service and bug reporting. In addition, the company provides its players a secure environment that features high-quality graphics and games.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and had participants from various geographical areas. This type of heterogeneity is essential for pragmatic trials to be valid and reduces the chance of bias in the results. Too much heterogeneity, however could cause issues with the design of the trial.

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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are usually requested by practitioners and 프라그마틱 순위 슬롯 사이트 [norwichterrierclub037bf.zapwp.com] policy makers to inform their decision making. They also provide a useful method to determine the cause-effect relationship between an intervention and its outcomes. However, they should not be used as a substitute for the use of explanation studies.

The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a practical study which includes recruitment, design, implementation of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these trials were conducted in primary care settings.