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Pragmatic trials are trials designed to inform real-world clinical practice. They are typically focused on practical aspects of the study design, such as recruitment and consent in adherence, as well as the use of standard equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from various geographical areas. This kind of heterogeneity, that is crucial for pragmatic trials to be valid and to reduce bias in the results is also essential. However excessive heterogeneity could cause issues with the design of the trial.
Pragmatic Play Pragmatic Play, one of the major players in the live casino market, offers various classic table games such as Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic gaming experience as well a full range of virtual betting options. The company also has created several interactive game shows to make online gambling enjoyable. Some of these shows feature live hosts, whereas others are hosted by prominent personalities from the industry.
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Legality
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The purpose of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are typically commissioned by policymakers and practitioners to help guide their decisions. They can also be used to assess the causal relationship between an intervention and its effects. However, they should not be used to replace the need for explanation studies.
The idea of pragmatism is controversial and there are doubts about whether pragmatic trials should replace tests for explanations or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove a physiological or clinical hypothesis, and pragmatic trials, which guide policy and practice decisions. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a pragmatic study that include the recruitment process, the design and implementation of the intervention, as well as monitoring.
The number of pragmatic trials is growing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the subject of pragmatics. It is important to note, however, that the majority of these studies were conducted in primary-care settings.