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Pragmatic trials are trials designed to provide information for the real-world practice of clinical. They are often focused on the practical aspects of the study design, including the recruitment process and consent in adherence, as well as the use of standard equipment.
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A pragmatic trial that uses a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for practical trials to be valid, and it also reduces the chance of bias in the results. However, too much heterogeneity can cause issues with the design of the trial.
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The goal of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are usually requested by practitioners and policy makers to guide their decision-making. They are also a good way to identify the cause-effect relationship between an intervention and its outcomes. However, they shouldn't be used as a substitute for explanation studies.
The idea of pragmatism is controversial and there are doubts about whether pragmatic trials should replace explanatory tests or 프라그마틱 슬롯체험 (Suggested Online site) if they are an addition to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study, including recruitment, design, delivery of the intervention and its follow-up.
There is an encouraging increase in the number pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This is a sign that the health sciences community is becoming more sensitive to the subject of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.