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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of designing a study, including the recruitment and consent process, as well as adherence and the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and included participants from different geographical regions. This type of heterogeneity, 프라그마틱 슬롯 무료체험 which is vital for pragmatic trials to be reliable and lessen the chance of bias is also essential. A high degree of heterogeneity, however could cause issues with the design of the trial.
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The goal of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are usually requested by practitioners and policy makers to inform their decision making. They can also be a great way to identify the cause-effect relationship between an intervention and its results. However, they should not be used in lieu for explanation studies.
The pragmatism concept is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 made the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a pragmatic trial, including recruitment, design and 프라그마틱 플레이 delivery of the intervention, and the follow-up.
There is a growing increase in the number pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, 프라그마틱 데모 (https://loiro.ru/Bitrix/redirect.php?goto=https://pragmatickr.com) which are shown in red in Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the subject of pragmatics. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.