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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often focused on the practical aspects of study design, including the recruitment process and consent in adherence, as well as the use of commonly available equipment.

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A practical trial that employs a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity and reduces bias in the results. However excessive heterogeneity could cause issues with the design of the trial.

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Legality

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The purpose of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can also be used to determine the causal relationship between an intervention and 프라그마틱 정품 사이트 its results. However, they should not be used as a substitute for explanatory trials.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they are an alternative to them. Schwartz and 프라그마틱 슬롯 무료 Lellouch1 suggested the distinction between explanation trials, which confirm a physiological or clinical hypothesis and pragmatic trials, which inform the policy and practice of. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a pragmatic study, including the recruitment process, the design and delivery of the intervention, and follow-up.

There is a positive increase in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note, however, that the majority of studies were conducted in primary care settings.