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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are typically described by their focus on practical aspects of designing a study, including the recruitment process and consent, adhering and the use routinely available equipment.

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A pragmatic study that involves a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be valid, and it also reduces the chance of bias in the results. A high degree of heterogeneity, however could cause issues with the design of the trial.

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Legality

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The aim of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can also be used to determine the cause-effect relationship of an intervention and 프라그마틱 슬롯무료 its effects. However, they should not be used as a substitute for explanatory trials.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a pragmatic study, including recruitment, design and delivery of the intervention, as well as the follow-up.

There is an encouraging increase in the number pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is a sign that the health sciences community is becoming more acquaint to the issue of pragmatics. It is important to keep in mind, however, that the majority of these studies were conducted in primary care settings.