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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized as focusing on practical aspects of designing a study that include recruitment and consent, adherence and the use routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from different geographical regions. This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity and helps reduce the chance of bias in the results. However too much heterogeneity could result in issues with the design of the trial.
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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. Usually, they are commissioned by policymakers and practitioners in order to inform their decisions. They can also be used to assess the cause-effect relationship of an intervention with its outcomes. However, they shouldn't be used to substitute for explanatory trials.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis as well as pragmatic trials, 프라그마틱 플레이 무료프라그마틱 슬롯 하는법; Https://Pragmatickrcom20864.Oblogation.Com/29349267/The-No-1-Question-Everybody-Working-In-Pragmatic-Authenticity-Verification-Must-Know-How-To-Answer, which inform the practice and policy decisions. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the elements of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, 프라그마틱 슬롯 팁 as well as follow-up.
There is a positive trend in the number of pragmatic trials published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.