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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically described as focusing on practical aspects of designing a study that include the recruitment process and consent, adhering and the use routinely available equipment.

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Pragmatic is a software developer that provides a variety of casino games available on online gambling platforms. Pragmatic's iGaming software is used by leading operators as well as land-based casinos. The company provides front-end tools for design, analysis, promotions, marketing payment systems, security, customer service and bug reporting. Additionally, the company provides its users a safe environment with high-quality graphics as well as games.

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A pragmatic study that involves a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for pragmatic trials to be reliable and reduce bias in results, is also necessary. However, too much heterogeneity, can cause problems with the trial design.

Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market, offers various classic table games, including Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta provide customers with an authentic gambling experience, as well a full selection of virtual betting options. The company has also created several interactive game shows to make gambling online enjoyable. Some of these shows are broadcast live, while others are hosted by famous personalities from the field.

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In addition to their mobile-friendly slot machines, Pragmatic Play also offers tables games and live dealer casinos. Pragmatic Play is licensed by several regulatory bodies, including Malta Gaming Authority and UK Gambling Commission. The games are protected by the latest encryption technology and the security team is ready to assist players resolve any issues they may have.

Pragmatic Play's slot games are a hit with newbies as well as experienced players. They have modern designs and traditional themes. Many of them offer progressive jackpots as well as numerous bonus rounds and paylines. They aren't volatile, so you can enjoy a long gaming experience.

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Legality

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The aim of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are typically commissioned by practitioners and policy makers to guide their decision-making. They are also a good method to determine the causality between an intervention and its results. However, they shouldn't be used to substitute for explanatory studies.

The concept of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they should serve as a complement to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study which includes recruitment, design, implementation of the intervention and its follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind that the majority of studies were conducted in primary-care settings.