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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are typically focused on the practical aspects of study design, such as recruitment and consent as well as adherence to the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and participants from different geographic areas. This kind of heterogeneity is essential for practical trials to be valid, and it also helps to reduce the chance of bias in the results. However excessive heterogeneity could lead to problems with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually commissioned by practitioners and policy makers to inform their decision making. They can be used to determine the causality of an intervention and its results. They should not, however, be used to replace explanatory studies.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they should be a complement to them. Schwartz and Lellouch1 made the distinction between explanation studies, which support a physiological hypothesis or clinical hypothesis, and 프라그마틱 무료스핀 pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic research study that includes recruitment, design, delivery of the intervention, and follow-up.

There is a growing increase in the number pragmatic trials published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health science community is becoming increasingly sensitized to the issue of pragmatics. It is important to note that the majority of these trials were conducted in primary care settings.