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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically described by their focus on practical aspects of study design, including the recruitment process and consent, adhering and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and had participants from different geographic areas. This type of heterogeneity is essential for practical trials to be valid and also helps to reduce the chance of bias in the results. A high degree of heterogeneity, however, can cause problems with the trial design.

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Legality

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Pragmatic trials aim to mimic real-world situations and 프라그마틱 슬롯 무료체험 have the highest external validity. They are typically commissioned by practitioners and policy makers to inform their decision making. They can also be used to determine the causal relationship between an intervention with its outcomes. However, they should not be used as a substitute for explanation studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove a physiological or clinical hypothesis as well as pragmatic trials that inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic study which includes recruitment, design, delivery of the intervention and follow-up.

There is an encouraging increase in the number pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.