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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often described as focusing on practical aspects of study design that include the recruitment process and consent, adhering and the use of standard equipment.
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A pragmatic trial that uses various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for pragmatic trials to be valid and to reduce bias in the results is also essential. However too much heterogeneity could lead to issues with the design of the trial.
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Mobile compatibility
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Legality
Pragmatic Play has earned a name for itself by providing top-quality games and an outstanding user experience. Its software can be used on mobile devices and in a variety of languages. It has established itself as one of the top gaming platforms in the casino industry despite its relatively young age. Its latest releases include Wolves, a 5-reel video slot with a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policy makers to aid in their decision-making. They can also be a great way to identify the causal relationship between an intervention and its outcomes. They should not, however be used to replace explanatory studies.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis, and pragmatic trials, which guide the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic study which includes the recruitment, design, and delivery of the intervention and its follow-up.
There is a positive trend in the number of pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to note that the majority of these studies were conducted in primary care settings.