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Pragmatic trials are those that are designed to provide information for real-world clinical practice. They are often described by their focus on practical aspects of study design which include recruitment and consent, adherence and the use of standard equipment.
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A pragmatic study that involves various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for practical trials to be valid and also helps reduce the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.
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Mobile compatibility
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Legality
Pragmatic Play has earned a reputation for providing top-notch games and an exceptional user experience. Its software can be used on mobile devices and in a variety of languages. It has earned itself the status of one of the leading gaming platforms in the casino industry despite its relative youth. Its latest releases include Wolves, a 5-reel video slot that has a healthy RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can be used to determine the causal relationship between an intervention and its effects. However, they should not be used to substitute for explanatory studies.
The pragmatism idea is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the elements of a practical study which includes the recruitment, design, and delivery of the intervention and its follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs), yielded 34 articles, as shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these trials were conducted in primary care settings.