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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described as a focus on the practical aspects of design that include recruitment and consent, adherence and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, 프라그마틱 무료체험 which used various investigators and had participants from different geographic areas. This kind of heterogeneity is required for pragmatic trials to be valid, and it also reduces bias in the results. Too much heterogeneity, however, can cause problems with the design of the trial.

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Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can be used to determine the causal relationship between an intervention and its effects. They should not, however be used to replace explanatory studies.

The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform policy and practice decision-making. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial that include the recruitment process, the design and delivery of the intervention, and monitoring.

The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatic thinking. It is important to note, however, that the majority were conducted in primary-care settings.