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Pragmatic trials are trials designed to inform real-world clinical practice. They are often characterized as a focus on the practical aspects of designing a study, including the recruitment and consent process, as well as adherence and the use routinely available equipment.
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Pragmatic Software, a software firm, offers a variety of casino games to online gambling platforms. Its iGaming solutions are used by the leading operators and casinos with a physical location. The company provides front-end tools for design, analysis, promotions, marketing payment systems, security, customer support and bug reporting. Additionally, the company provides its players a safe and secure environment that features high-quality graphics and games.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from different geographical regions. This type of heterogeneity is required for pragmatic trials to be able to prove their validity and helps reduce bias in the results. Too much heterogeneity, however can result in problems with the trial design.
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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually commissioned by policymakers and practitioners in order to inform their decisions. They are also a good way to identify the causality between the intervention and its effects. They should, however, not, be used to replace the need for explanation studies.
The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also suggested a framework for 프라그마틱 무료 환수율 (metooo.co.Uk) pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic study which includes the recruitment process, the design and implementation of the intervention, and monitoring.
The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.