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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized as a focus on the practical aspects of design that include the recruitment and consent process, as well as adherence and the use of standard equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and had participants from different geographic areas. This kind of heterogeneity is necessary for pragmatic trials to be valid and 프라그마틱 슬롯버프 helps to reduce bias in the results. A high degree of heterogeneity, 프라그마틱 무료 슬롯 프라그마틱 슬롯 사이트무료 (Greatbookmarking.com) however can result in problems with the design of the trial.
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The purpose of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. They are typically ordered by policymakers and practitioners in order to inform their decisions. They also provide a useful method of determining the causality between an intervention and its outcomes. However, they shouldn't be used in lieu for explanation trials.
The pragmatism concept is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the practice and policy decision-making. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a pragmatic study, 프라그마틱 공식홈페이지 정품 사이트; Cyberbookmarking.com, including recruitment, design and delivery of the intervention, as well as follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.