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Pragmatic trials are those that are designed to inform the real-world practice of clinical. They are typically described as a focus on the practical aspects of study design that include the recruitment process and consent, adhering and the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from different geographical regions. This kind of heterogeneity is necessary for pragmatic trials to be valid, and it also helps to reduce bias in the results. However excessive heterogeneity could lead to problems with the design of the trial.
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Pragmatic Play has gained a reputation for offering high-quality games and a superior user experience. Its software can be used on mobile devices as well as in various languages. Despite its relative youth, it has already established itself as a leading gaming platform for casinos. Wolves is one of the latest games that is a 5-reel slot machine that has a high RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policymakers in order to inform their decisions. They can also be used to assess the causality of an intervention and its effects. They should not, however be used to replace explanation studies.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a practical trial which includes the recruitment process, the design and delivery of the intervention, as well as monitoring.
There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs), yielded 34 articles, as shown in red in Figure 2. This is an indication that the health science community is becoming more acquaint to the subject of pragmatic thinking. It is important to note that the majority of studies were conducted in primary-care settings.