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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often described as a focus on the practical aspects of design that include recruitment and 프라그마틱 슬롯 무료 consent, adherence and the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, 프라그마틱 슬롯 조작 슬롯무료 (Clashofcryptos.Trade) which utilized various investigators and included participants from different geographical regions. This type of heterogeneity is required for pragmatic trials to be valid, and it also helps to reduce the chance of bias in the results. However excessive heterogeneity could cause issues with the design of the trial.
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The aim of pragmatic trials is to replicate real-life scenarios and 프라그마틱 데모 무료체험 슬롯버프 (Read Home Page) gain the highest level of validity externally. They are usually requested by practitioners and policy makers to aid in their decision-making. They can be used to determine the causal relationship between an intervention with its outcomes. However, they shouldn't be used to substitute for explanation studies.
The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial which includes the recruitment process, the design and delivery of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is an indication that the health science community is becoming more acquaint to the issue of pragmatics. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.