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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are often described by their focus on practical aspects of study design, including recruitment and consent, adherence and the use of standard equipment.

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A practical trial that employs different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for a pragmatic trial to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity could cause issues with the design of the trial.

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The goal of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are typically commissioned by policymakers and practitioners to guide their decisions. They can also be used to determine the causality of an intervention and its effects. However, they shouldn't be used as a substitute for explanation trials.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, 프라그마틱 무료슬롯, yd.yichang.cc, which inform the decision-making process for policy and practice. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic study, including the recruitment process, the design and delivery of the intervention, as well as follow-up.

There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is a sign that the health sciences community is becoming more sensitive to the subject of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.